Now showing items 621-640 of 4850

    • Jiménez Gallegos, Danica Pamela (Universidad de Chile, 2019)
      Luego de un infarto al miocardio, el corazón se repara mediante un proceso denominado fibrosis cardíaca, en el cual los cardiomiocitos muertos son reemplazados por una cicatriz de matriz extracelular (MEC), conformada ...
    • Sanhueza Díaz, Sebastián Andrés (Universidad de Chile, 2020)
      Cerca de la mitad de los errores de medicación (EMs) se dan en un contexto de transición asistencial. Estos EMs se conocen como errores de conciliación (ECs) y corresponden a discrepancias no justificadas (DNJ) entre la ...
    • Ramos, Thaís; Maracajá Coutinho, Vinicius; Ortega, J. Miguel; Do Rego, Thais G. (BMC, 2020)
      Objective Data normalization and clustering are mandatory steps in gene expression and downstream analyses, respectively. However, user-friendly implementations of these methodologies are available exclusively under expensive ...
    • Oyarce Bravo, Álvaro (Universidad de Chile, 2020)
      Los pacientes críticos ingresados a la Unidad de Cuidados Intensivos (UCI) son sometidos a diversos procedimientos invasivos, los cuales pueden causar dolor y agitación en los pacientes. Para evitar que esto suceda es ...
    • Kim, Soo Young; Zhang, Xin; Schiattarella, Gabriele G.; Altamirano, Francisco; Ramos, Thais; French, Kristin M.; Jiang, Nan; Szweda, Pamela A.; Evers, Bret M.; May, Herman; Luo, Xiang; Li, Hongliang; Szweda, Luke; Maracajá Coutinho, Vinicius; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2020)
      BACKGROUND: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, ...
    • Gil, Yolimar; Fuentealba, Pablo; Vega, Andrés; Spodine Spiridonova, Evgenia; Aravena, Daniel (Royal Soc. Chemistry, 2020)
      A family of hexaazamacrocyclic lanthanide complexes, [Ln(L-n)(NCS)(3)] (Ln(III) = Dy, Er; n = 1-3) has been synthesized and characterized by single-crystal X-ray diffraction, magnetic measurements and ab initio calculations. ...
    • Heras, Violeta; Castellano, Juan Manuel; Fernandois, Daniela; Velasco, Inmaculada; Rodríguez Vázquez, Elvira; Roa, Juan; Vázquez, María Jesús; Ruiz Pino, Francisco; Rubio, Matías; Pineda, Rafael; Torres, Encarnación; Avendaño, María Soledad; Paredes Vargas, Alfonso; Pinilla, Leonor; Belsham, Denise; Dieguez, Carlos; Gaytan, Francisco; Casals, Nuria; López, Miguel; Tena Sempere, Manuel (Cell, 2020)
      Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ...
    • Veneciano, Rodrigo I.; Parra, V. Sonnia; Quiroz, Waldo; Fuentes Pérez, Edwar; Aguilar, Luis F.; Bravo, Manuel A. (Elsevier, 2020)
      In this work, an analytical method for deltamethrin determination in natural waters based on photochemicallyinduced fluorescence coupled to third-order/four-way calibration was evaluated and compared with secondorder/three-way ...
    • Chou, Wai-Houng; Galaz, Ariel; Jara, Miguel O.; Gamboa, Alexander; Morales Montecinos, Javier (MDPI, 2020)
      The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive ...
    • Yévenes, Gonzalo E.; Bravo, Javier A.; Díaz Araya, Guillermo; Sotomayor Zárate, Ramón; Fiedler Temer, Jenny; Reyes Parada, Miguel; Fuentealba, Jorge (Frontiers Media, 2020)
    • DebRoy, Sruti; Aliaga Tobar, Víctor; Gálvez, Gabriel; Arora, Srishtee; Liang, Xiaowen; Horstmann, Nicola; Maracajá Coutinho, Vinicius; Latorre Mora, Mauricio; Hook, Magnus; Flores, Anthony; Shelburne, Samuel A. (Wiley, 2020)
      Catabolite control protein A (CcpA) is a master regulator of carbon source utilization and contributes to the virulence of numerous medically important Gram-positive bacteria. Most functional assessments of CcpA, including ...
    • Bejarano, Julián; Rojas, Aldo; Ramírez Sagredo, Andrea; Riveros Salvatierra, Ana; Morales Zavala, Francisco; Flores, Yvo; Riquelme Meléndez, Jaime; Guzmán, Fanny; Araya, Eyleen; Chiong Lay, Mario; Ocaranza, María Paz; Morales Montecinos, Javier; Villamizar Sarmiento, María Gabriela; Sánchez Vergara, Gina; Lavandero González, Sergio; Kogan, Marcelo J. (Elsevier, 2020)
      Angiotensin-(1-9), a component of the non-canonical renin-angiotensin system, has a short half-life in blood. This peptide has shown to prevent and/or attenuate hypertension and cardiovascular remodeling. A controlled ...
    • Alvarado Díaz, Carlos; Valenzuela, María L.; Cifuentes Vaca, Olga; Segovia, Marjorie; Laguna Bercero, Miguel A. (MDPI, 2020)
      The medium effect of the optical and catalytic degradation of methylene blue was studied in the NiO/SiO2, NiO/TiO2, NiO/Al2O3, and NiO/Na4.2Ca2.8(Si6O18) composites, which were prepared by a solid-state method. The new ...
    • Cáceres, Denisse; Giménez, Begoña; Marquez Ruiz, Gloria; Holgado, Francisca; Vergara, Cristina; Romero Hasler, Patricio; Soto Bustamante, Eduardo; Robert Canales, Paz (MDPI, 2020)
      Purified walnut oil (PWO) microparticles with Capsul(R) (C, encapsulating agent), sodium alginate (SA) as outer layer and ascorbic acid (AA) as oxygen scavenger were obtained by spray drying using a three-fluid nozzle. AA ...
    • Chaudhry, Farhan; Lavandero González, Sergio; Xie, Xiang; Sabharwal, Basera; Zheng, Ying-Ying; Correa, Ashish; Narula, Jagat; Levy, Phillip (BMJ, 2020)
      SARS-CoV-2 is the virus responsible for the ongoing COVID-19 outbreak. The virus uses ACE2 receptor for viral entry. ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the ...
    • Greatti, Vanessa Raquel; Oda, Fernando; Sorrechia, Rodrigo; Kapp, Bárbara Regina; Seraphim, Carolina Manzato; Villas Boas Weckwerth, Ana Carolina; Chorilli, Marlus; Da Silva, Patricia Bento; Eloy, Josimar O.; Kogan, Marcelo J.; Morales Montecinos, Javier; Linhari Rodrigues Pietro, Rosemeire Cristina (MDPI, 2020)
      Dermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal ...
    • Mella Raipán, Jaime; Romero Parra, Javier; Recabarren Gajardo, Gonzalo (American Chemical Society, 2020)
      Opioids are arguably one of the most important pharmacologic classes, mainly due to their rich history, their useful and potent analgesic effects, and also, just as importantly, their “Dark Side”, constituted by their ...
    • Muñoz Ramírez, Alejandra; Mascayano Collado, Carolina; Barriga, Andrés; Echeverría, Javier; Urzúa, Alejandro (Frontiers Media, 2020)
      Lithraea caustica (Molina) Hook. and Arn. (Anacardiaceae), common name Litre, is an evergreen endemic plant used in the Mapuche Chilean folk medicine. The stem juice of L. caustica mixed with Rubus ulmifolius (blackberry) ...
    • Barrientos, C; Navarrete Encina, P.; Squella Serrano, Juan (Electrochemical Soc Inc, 2020)
      The present studies reveal superoxide radical anion reactivity against synthesized coumarins. Free radicals play an important role in many diseases and they have a protective function also. Therefore, we must keep a balance ...
    • Contreras, G.; Barrientos, C; Moscoso, R.; Álvarez Lueje, Alejandro; Squella Serrano, Juan (Elsevier, 2020)
      In this work, we have both synthesized and studied 4-phenylbutyl-3,5-dinitrobenzoate (3,5-DNBPh) as a potential precursor of an electrocatalytic mediator for the oxidation of NADH, with the di-nitro compound immobilized ...