Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 561-580 of 4850

    • UHPLC-MS chemical fingerprinting and antioxidant, antiproliferative, and enzyme inhibition potential of ... 
      Fernández Galleguillos, Carlos; Quesada Romero, Luisa; Puerta, Adrián; Padrón, José M.; Souza, Ernane; Romero Parra, Javier Hernán; Simirgiotis, Mario J. (MDPI, 2021)
      Gaultheria pumila (Ericaceae) (known as Chaura or Mutilla) is a Chilean native small shrub that produces berry fruits consumed by local Mapuche people. In this study, the chemical fingerprinting and antioxidant, enzyme ...
    • Analysis of carotenoids in haloarchaea species from Atacama saline lakes by high resolution UHPLC-Q-Orbitrap-Mass ... 
      Lizama, Catherine; Romero Parra, Javier Hernán; Andrade, Daniel; Riveros, Felipe; Bórquez, Jorge; Ahmed, Shakeel; Venegas Salas, Luis; Cabalín, Carolina; Simirgiotis, Mario J. (MDPI, 2021)
      Haloarchaea are extreme halophilic microorganisms belonging to the domain Archaea, phylum Euryarchaeota, and are producers of interesting antioxidant carotenoid compounds. In this study, four new strains of Haloarcula sp., ...
    • Nanoparticles as potential novel therapies for urinary tract infections 
      Sánchez, Sofía V.; Navarro Martínez, Nicolás Matías; Catalán Figueroa, Johanna; Morales Montecinos, Javier Octavio (Frontiers Media, 2021)
      Urinary tract infection (UTI) is one of the most common reasons for antibiotic treatment. Nevertheless, uropathogens are steadily becoming resistant to currently available therapies. In this context, nanotechnology emerges ...
    • Study of different chitosan/sodium carboxymethyl cellulose proportions in the development of polyelectrolyte ... 
      Guarnizo Herrero, Víctor; Torrado Salmeron, Carlos; Torres Pabón, Norma; Torrado Durán, Guillermo; Morales, Javier; Torrado-Santiago, Santiago (MDPI, 2021)
      This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release ...
    • A brief review on the high-energy electromagnetic radiation-shielding materials based on polymer nanocomposites 
      Acevedo del Castillo, Ángel; Águila Toledo, Ernesto; Maldonado Magnere, Santiago Ignacio; Aguilar Bolados, Héctor Esteban (MDPI, 2021)
      This paper revises the use of polymer nanocomposites to attenuate high-energy electromagnetic radiation (HE-EMR), such as gamma radiation. As known, high-energy radiation produces drastic damage not only in facilities or ...
    • Loss of social/non-social context discrimination by movement acceleration in the valproate model of autism 
      Quezada, Nelva T.; Salas Ortiz, Sebastiana F.; Peralta, Francisco A.; Aguayo Abarca, Felipe Ignacio; Morgado Gallardo, Katherine P.; Mac-Rae, Catherine A.; Fiedler Temer, Jenny Lucy; Aliaga, Esteban E. (Frontiers Media, 2021)
      Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information ...
    • Deletion of hippocampal glucocorticoid receptors unveils sex-biased microRNA expression and neuronal ... 
      Tejos Bravo, Macarena Verónica Monserrat; Oakley, Robert H.; Whirledge, Shannon D.; Corrales Ibáñez, Wladimir Antonio; Silva, Juan Pablo; García Rojo, Gonzalo Javier; Toledo, Jorge; Sánchez, Wendy; Román Albasini, Luciano Paolo; Aliaga, Esteban; Aguayo Abarca, Felipe Ignacio; Olave Olave, Felipe Antonio; Maracaja Coutinho, Vinicius; Cidlowski b, John A.; Fiedler Temer, Jenny Lucy (Elsevier, 2021)
      Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
    • Development and validation of a multi-locus PCR-HRM method for species identification in mytilus genus with ... 
      Quintrel Curinao, Marianela Verónica; Jilberto, Felipe; Sepúlveda, Matías; Marín Sánchez, María Elisa; Véliz Baeza, David Enrique; Araneda Tolosa, Cristian; Larraín Barth, María Angélica (MDPI, 2021)
      DNA-based methods using informative markers such as single nucleotide polymorphism (SNPs) are suitable for reliable species identification (SI) needed to enforce compliance with seafood labelling regulations (EU No.1379/2013). ...
    • Cooperative binding of ETS2 and NFAT links erk1/2 and calcineurin signaling in the pathogenesis of cardiac ... 
      Luo, Yuxuan; Jiang, Nan; May, Herman I.; Luo, Xiang; Ferdous, Anwerul; Schiattarella, Gabriele G.; Chen, Guihao; Li, Qinfeng; Li, Chao; Rothermel, Beverly A.; Jiang, Dingsheng; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2021)
      Background: Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK ...
    • Characterization and antimicrobial activity of microencapsulated citral with dextrin by spray drying 
      Yoplac, Ives; Vargas, Luis; Robert Canales, Paz Soledad; Hidalgo, Alyssa (Elsevier, 2021)
      Aim of this work was to evaluate the antimicrobial activity and physical characteristics of citral microencapsulated with dextrin (Dx) by spray drying. The encapsulation was optimized using response surface methodology ...
    • Insights of the formation mechanism of nanostructured titanium oxide polymorphs from different macromolecular ... 
      Allende, Patricio; Orera, Alodia; Laguna Bercero, Miguel A.; Valenzuela, María Luisa; Díaz, Carlos; Barrientos, Lorena (Elsevier, 2021)
      The insight into the mechanism of the unprecedented formation of pure anatase TiO2 from the macromolecular (Chitosan)center dot(TiOSO4)(n) precursor has been investigated using micro Raman spectroscopy, Scanning Electron ...
    • Determination of bioactive compounds in sequential extracts of chia leaf (salvia hispanica l.) using ... 
      Zúñiga López, María Carolina; Maturana, Gabriela; Campmajó, Guillem; Saurina, Javier; Núñez, Óscar (MDPI, 2021)
      Consumers' interest in foods that are nutritionally balanced and with health benefits has increased. The food industry is paying attention to the use of the ancestral seed Salvia hispanica L., commonly known as chia. At ...
    • The influence of size and chemical composition of silver and gold nanoparticles on in vivo toxicity with ... 
      Báez, Daniela F.; Gallardo Toledo, Eduardo Ignacio; Oyarzun, María Paz; Araya, Eyleen; Kogan, Marcelo Javier (Dovepress, 2021)
      The physicochemical and optical properties of silver nanoparticles (SNPs) and gold nanoparticles (GNPs) have allowed them to be employed for various biomedical applications, including delivery, therapy, imaging, and as ...
    • Novel N-arylsulfonylindoles targeted as ligands of the 5-HT6 receptor. Insights on the influence of C-5 ... 
      Arrieta Rodríguez, Loreto; Espinoza Rosales, Daniela; Vera, Gonzalo; Cho, Young Hwa; Cabezas, David; Vásquez Velásquez, David Reinaldo; Mella Raipán, Jaime; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo (MDPI, 2021)
      A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the ...
    • Novel template plasmids pCyaA’-Kan and pCyaA’-Cam for generation of unmarked chromosomal cyaA’ translational ... 
      Fernández Oyarzún, Paulina Alejandra; Zabner Espinoza, Marcela Estefanía; Ortega Berríos, Jaime Ignacio; Morgado Ruiz, Constanza Patricia; Amaya Inzunza, Fernando Andrés; Vera Sánchez, Gabriel Alberto; Rubilar Leyton, Carolina Andrea; Salas Valenzuela, Beatriz Elizabeth; Cuevas, Víctor; Valenzuela Montenegro, Camila; Baisón Olmo, Fernando; Álvarez Armijo, Sergio Aníbal; Santiviago Cid, Carlos Alberto (MDPI, 2021)
      The type III secretion systems (T3SS) encoded in pathogenicity islands SPI-1 and SPI-2 are key virulence factors of Salmonella. These systems translocate proteins known as effectors into eukaryotic cells during infection. ...
    • Case report: molecular features and treatment options for small bowel adenocarcinoma 
      Córdova Delgado, Miguel Angel; Pizarro, Gonzalo; Pinto, Mauricio P.; Herrera, María Elisa; Garrido, Marcelo (Frontiers Media, 2021)
      Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main ...
    • Development of a nanostructured lipid carrier (nlc) by a low-energy method, comparison of release kinetics ... 
      Ortiz, Andrea C.; Yáñez, Osvaldo; Salas Huenuleo, Edison Sebastián; Morales Montecinos, Javier Octavio (MDPI, 2021)
      Lipid nanocarriers have a great potential for improving the physicochemical characteristics and behavior of poorly water-soluble drugs, such as aqueous dispersibility and oral bioavailability. This investigation presents ...
    • Dependence of the Ripeness Stage on the Antioxidant and Antimicrobial Properties of Walnut (Juglans regia ... 
      Soto Madrid, Daniela; Gutiérrez Cutiño, Marlene; Pozo Martínez, Josué Santiago; Zúñiga López, María Carolina; Olea Azar, Claudio Alberto; Matiacevich, Silvia (MDPI, 2021)
      Walnut green husk (WGH) is a waste generated by the walnut (Juglans regia L.) harvest industry. It represents a natural source of polyphenols, compounds with antioxidant and antimicrobial activities, but their activity ...
    • Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents 
      Salgado, Francisco; Moncada Basualto, Mauricio Javier; Pozo Martínez, Josué Santiago; Liempi, Ana; Kemmerling Weis, Ulrike; Maya Arango, Juan Diego; Jaque Olmedo, Pablo César; Borges, Fernanda; Uriarte, Eugenio; Matos, María J.; Olea Azar, Claudio Alberto (Elsevier, 2021)
      Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. ...
    • Automated generation of context-specific gene regulatory networks with a weighted approach in Drosophila ... 
      Murgas, Leandro; Contreras Riquelme, Sebastián; Martínez Hernández, Jesús Eduardo; Villaman, Camilo; Santibáñez, Rodrigo; Martín, Alberto J. M. (Royal Soc, England, 2021)
      The regulation of gene expression is a key factor in the development and maintenance of life in all organisms. Even so, little is known at whole genome scale for most genes and contexts.We propose a method, Tool forWeighted ...